Gram Scale Conversion ofR-BINAM toR-NOBIN

A Method for Chromosome Handling ofr -

Gram-scale synthesis of iejimalide B.

Iejimalide B (2) is the most promising member of a small family of marine polyene macrolides endowed with remarkably selective activity against human cancer cell lines. As this product, however, is hardly available from the natural sources, a detailed evaluation requires the development of an efficient and practical synthetic approach. This challenge has now been met by adapting the first total...

Failure transitions for joint n-gram models and G2p conversion

This work investigates two related issues in the area of WFSTbased G2P conversion. The first is the impact that the approach utilized to convert a target word to an equivalent finite-state machine has on downstream decoding efficiency. The second issue considered is the impact that the approach utilized to represent the joint n-gram model via the WFST framework has on the speed and accuracy of ...

Studies towards the N-acylative Kinetic Resolution of Nobin

2-Amino-2′-hydroxy-1,1′-binaphthyl [NOBIN (1); Fig. 1] was first prepared as a racemate by Kočovský in 1991 via oxidative coupling of 2-naphthol and 2-naphthylamine in MeOH using stoichiometric tert-butylamine/ copper(II) chloride1–3. Subsequently, a variant employing aqueous iron(III) chloride was reported4,5, and (±)-NOBIN has been prepared from (±)-BINOL (3; Fig. 1) by a Bucherer reaction6. ...

Effect of vergence on human ocular following response (OFR).

The human ocular following response (OFR) is a preattentive, short-latency visual-field-holding mechanism, which is enhanced if the moving stimulus is applied in the wake of a saccade. Since most natural gaze shifts incorporate both saccadic and vergence components, we asked whether the OFR was also enhanced during vergence. Ten subjects viewed vertically moving sine-wave gratings on a video mo...